Multiple Subcutaneous Masses With Cytologic Findings Consistent With Liposarcoma

  • Post last modified:August 29, 2026
  • Reading time:2 mins read

Small lumps can look harmless. Sometimes, they deserve a much closer look.

This patient was presented with several small, separate masses located in different areas of the body. None of them appeared particularly dramatic at first glance, which is exactly why cases like this can be easy to underestimate.

A lump’s size, softness, or appearance alone cannot reliably tell us whether it is benign or malignant. Some tumors may feel similar to ordinary fatty masses, while others remain small even when the underlying cells are abnormal.

To investigate further, samples were collected through fine-needle aspiration, a minimally invasive procedure in which a small needle is inserted into a mass to obtain cells for microscopic examination. Cytology revealed cellular features consistent with liposarcoma, a malignant tumor arising from adipocytic, or fat-producing, tissues.

Cytology is valuable because it can help veterinarians determine the likely nature of a mass and guide the next clinical step. However, when a malignant tumor is suspected, histopathologic examination of the surgically removed tissue remains important for more definitive characterization and assessment of tumor margins.

Because this patient had multiple distinct masses, surgery required careful planning. Each palpable and visible lesion had to be located individually, excised as completely as reasonably possible, and separated from surrounding healthy tissue while minimizing unnecessary tissue trauma.

The photograph shows several of the excised masses following surgery.

Post-operatively, the patient recovered well and continues to do well at this time. Continued monitoring remains important because malignant tumors can recur locally or, depending on tumor behavior and type, potentially spread elsewhere.

For pet owners, the most important lesson from this case is simple: a lump does not have to be large to deserve attention. New, growing, firm, irregular, changing, or multiple masses should be assessed rather than judged by appearance alone.

At AVCI, evaluation of a mass may involve physical examination, fine-needle aspiration and cytology, diagnostic imaging when indicated, surgical planning, and follow-up based on the individual case.

If you notice a new lump on your dog or cat, especially one that is changing or accompanied by additional masses, have it checked early. The sooner we understand what it is, the sooner we can decide what should—or should not—be done next.

Case handled by Dr. Jessica E. Bacalan.

Picture of Dr. Jessica E. Bacalan

Dr. Jessica E. Bacalan

Attending Veterinarian