They are known to enhance the immune system’s ability to recognize and eliminate abnormal cells, including cancer cells. In the context of mammary tumors, DLE have been suggested to support the immune response against tumor cells, potentially leading to tumor regression and improved outcomes. While the exact mechanism of action of DLE in mammary tumors is still under investigation, it is believed to enhance the activity of immune cells such as natural killer cells and cytotoxic T cells, which are crucial in combating cancer.

Herbal Mixture and Anti-Cancer Effects

Glycyrrhiza glabra (licorice), Camellia sinensis (green tea), and Cinnamomum verum (cinnamon) are herbs known for their potential anti-cancer properties. Glycyrrhiza glabra contains various bioactive compounds, including glycyrrhizin, which has been reported to exhibit anti-inflammatory and anti-tumor effects. Studies have suggested that Glycyrrhiza glabra may inhibit the growth and proliferation of cancer cells, including those found in mammary tumors.

Camellia sinensis, commonly known as green tea, is rich in polyphenols, particularly catechins such as epigallocatechin gallate (EGCG). These compounds have demonstrated antioxidant, anti-inflammatory, and anti-cancer properties. Research has shown that green tea catechins can modulate multiple signaling pathways involved in tumor development and inhibit the growth of cancer cells.

Cinnamomum verum, or true cinnamon, contains various bioactive compounds such as cinnamaldehyde, cinnamic acid, and cinnamate. These compounds possess antioxidant and anti-inflammatory properties and have been investigated for their potential anti-cancer effects. Studies suggest that Cinnamomum verum may exhibit cytotoxic activity against cancer cells, including those associated with mammary tumors.

Treatment Outcome

Following three weeks of treatment with DLE and the herbal mixture, the canine patient experienced a significant reduction in mammary gland swelling, and no palpable lumps were detected. These favorable outcomes indicate a positive response to the treatment regimen. Notably, a repeat biopsy was not performed to confirm the absence of the lipoma or any changes in its classification.

Conclusion

This case study highlights the potential benefits of using DLE and a herbal mixture containing Glycyrrhiza glabra, Camellia sinensis, and Cinnamomum verum in the treatment of a canine patient presenting with lumps on its posterior mammary glands. DLE’s immune-modulating properties may have contributed to the observed reduction in swelling and the absence of palpable lumps. Additionally, the potential anti-cancer effects of Glycyrrhiza glabra, Camellia sinensis, and Cinnamomum verum may have played a role in this positive outcome. While these results are promising, further research is needed to elucidate the mechanisms and efficacy of these treatment approaches in the management of mammary tumors and lipomas in dogs.