Q: What should I know about Parvovirus 2c?

This is the newest type of parvovirus to afflict dogs. It was first detected in Italy in 2000 and has caused outbreaks all over the world with official reports from India in 2010, from China in 2014, from Taiwan in 2015, and from both Vietnam and Laos in 2016.

Q: Is Parvovirus 2c unique?

Unlike older types of parvovirus that mainly affect pups, parvovirus 2c is unique because it has been reported to affect young adults and completely vaccinated dogs up to 3 years of age.

Q: What are the clinical signs of Parvovirus 2c?

Parvovirus 2c has the same clinical signs as that with the other types of parvovirus – vomiting, bloody diarrhea, and eventually death. However, reports are piling up that parvovirus 2c causes a more severe disease in pets.

Q: What are the different types of Parvovirus?

The first parvovirus to adversely affect dogs was detected in 1978. It was identified as canine parvovirus type 2 (CPV-2). CPV-2a was later identified in 1979, and CPV-2b soon emerged in 1984. It was in the year 2000 that CPV-2c made its presence felt. To summarize, the different types of parvovirus according to year of identfication are as follows:

  • 1978 – CPV-2
  • 1979 – CPV-2a
  • 1984 – CPV-2b
  • 2000 – CPV-2c
Q: Can regular Parvovirus vaccines protect dogs from Parvovirus 2c?

The known types of parvovirus are CPV-2, CPV-2a, CPV-2b & CPV-2c. Regular parvovirus vaccines are derived from either CPV-2 or CPV-2a. Unfortunately, regular vaccines extend protection only up to CPV-2b but not much on CPV-2c. On the other hand, CPV-2c vaccines only extend protection up to CPV-2b but also not much on CPV-2 and CPV-2a. To solve this dilemma, researchers created a CPV-2b vaccine, such as Biocan® Novel, that can give protection either way covering CPV-2c and extending back to CPV-2 & CPV-2a.

Q: Is Parvovirus-2c existing in the Philippines?

No official report has yet been made but individual scientific studies have detected CPV-2c in the Philippines. Yet despite the absence of an official report, unusual parvoviral outbreaks involving young adults and completely vaccinated dogs have been reported all over the country. Per experience at AVCI [as of June 2019], we started to encounter these unusual cases back in 2012. Supposed to be a disease involving only pups, we are now commonly handling parvoviral cases of completely vaccinated dogs up to 4 years of age.

References:

1) Buonavoglia C., Martella V., Pratelli A., Tempesta M., Cavalli A., Buonavoglia D., Bozzo G., Elia G., Decaro N. & Carmichael L. 2001. Evidence for evolution of canine parvovirus type 2 in Italy. J. Gen. Virol. 82:3021-3025.

2) Cargnelutti J, Masuda E, Fighera R, Kommers G, da Silva M, Weiblen R, Flores E. 2018. Epidemiological, clinical and pathological features of canine parvovirus 2c infection in dogs from southern Brazil. Pesq. Vet. Bras. vol.38 no.1 Rio de Janeiro.

3) Chiang SY, Wu HY, Chiou MT, Chang MC, Lin CN. 2016. Identification of a novel canine parvovirus type 2c in Taiwan. Virol J. 13:160.

4) Decaro N, Buonavoglia C. 2012. Canine parvovirus: a review of epidemiological and diagnostic aspects, with emphasis on type 2c. Vet. Microbiol. 155:1-12.

5) Decaro N, Desario C, Elia G, Martella V, Mari V, Lavazza A, Nardi M, Buonavoglia C. 2008. Evidence for immunisation failure in vaccinated adult dogs infected with canine parvovirus type 2c. New Microbiol. 31:125-30.

6) Jiang F. 2018. Bioclimatic and altitudinal variables influence the potential distribution of canine parvovirus type 2 worldwide. Ecol Evol. 8:4534-4543.

7) Hoang M, Lin WH, Le VP, Nga BTT, Chiou MT, Lin CN. 2019. Molecular epidemiology of canine parvovirus type 2 in Vietnam from November 2016 to February 2018. Virol J. 16:52.

8) Lin YC, Chiang SY, Wu HY, Lin JH, Chiou MT, Liu HF, Lin CN. 2017. Phylodynamic and Genetic Diversity of Canine Parvovirus Type 2c in Taiwan. Int J Mol Sci. 18:2703.

9) Miranda C., Parrish C.R. & Thompson G. 2014. Canine parvovirus 2c infection in a cat with severe clinical disease. J. Vet. Diagn. Invest. 26:462-464.

10) Miranda C, Thompson G. 2016. Canine parvovirus in vaccinated dogs: a field study. Vet Rec. 178:397.

11) Nandi S, Chidri S, Kumar M, Chauhan RS. 2010. Occurrence of canine parvovirus type 2c in the dogs with haemorrhagic enteritis in India. Res Vet Sci. 88:169-71.

12) Vannamahaxay S, Vongkhamchanh S, Intanon M, Tangtrongsup S, Tiwananthagorn S, Pringproa K, Chuammitri P. 2017. Molecular characterization of canine parvovirus in Vientiane, Laos. Arch Virol. 162:1355-1361.

13) Wilson S, Illambas J, Siedek E, Stirling C, Thomas A, Plevov E, Sture G, Salt J. 2014. Vaccination of dogs with canine parvovirus type 2b (CPV-2b) induces neutralising antibody responses to CPV-2a and CPV-2c. Vaccine. 32:5420-4.

14) Wilson S, Stirling C, Borowski S, Thomas A, King V, Salt J. 2013. Vaccination of dogs with Duramune DAPPi+LC protects against pathogenic canine parvovirus type 2c challenge. Vet Rec. 172:662.

15) Woolford L, Crocker P, Bobrowski H, Baker T, Hemmatzadeh F. 2017. Detection of the Canine Parvovirus 2c Subtype in Australian Dogs. Viral Immunol. 30:371-376.

16) Zhao H, Wang J, Jiang Y, Cheng Y, Lin P, Zhu H, Han G, Yi L, Zhang S, Guo L, Cheng S. 2015. Typing of Canine Parvovirus Strains Circulating in North-East China. Transbound Emerg Dis. 64:495-503.

This site uses Akismet to reduce spam. Learn how your comment data is processed.